Glucose production by the human kidney--its importance has been underestimated.

1. Noel J, Pouyssegur J. Hormonal regulation, pharmacology, and membrane sorting of vertebrate N a + / H + exchanger isoforms. Am J Physiol 1995; 268:C283-296 2. Orlowski J, Kandasamy RA, Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. J Biol Chem 1992; 267:9331-9339 3. Aronson PS. Ion exchangers mediating NaCl transport in the proximal tubule. Wien Klin Wochenschr 1997; 109: 435-440 4. Rosskopf D, Dusing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension 1993; 21: 607-617 5. Ng LL, Fennell DA, Dudley C. Kinetics of the human leucocyte Na + -H antiport in essential hypertension. / Hypertens 1990; 8: 533-537 6. Davies JE, Ng LL, Ameen M, Syme PD, Aronson JK. Evidence for altered N a + / H + antiport activity in skeletal muscle cells and vascular smooth muscle cells of the spontaneously hypertensive rat. ClinSci 1991; 80: 509-516 7. Rosskopf D, Fromter E, Siffert W. Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. A cell culture model for human hypertension. J Clin Invest 1993; 92: 2553-2559 8. Ng LL, Sweeney FP, Siczkowski M, Davies JE, Quinn PA, Krolewski B, Krolewski AS. N a + / H + antiporter phenotype, abundance and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension 1995; 25: 971-977 9. Sweeney FP, Quinn PA, Ng LL. Enhanced Mitogen-activated protein kinase activity and phosphorylation of the Na + /H + exchanger isoform 1 of human lymphoblasts in hypertension. Metabolism 1997; 46: 297-302